2007
Multiple Origins of Knockdown Resistance Mutations in the Afrotropical Mosquito Vector Anopheles gambiae
Pinto J, Lynd A, Vicente J, Santolamazza F, Randle N, Gentile G, Moreno M, Simard F, Charlwood J, do Rosário V, Caccone A, della Torre A, Donnelly M. Multiple Origins of Knockdown Resistance Mutations in the Afrotropical Mosquito Vector Anopheles gambiae. PLOS ONE 2007, 2: e1243. PMID: 18043750, PMCID: PMC2080755, DOI: 10.1371/journal.pone.0001243.Peer-Reviewed Original ResearchConceptsResistance allelesMutation eventsMosquito vector Anopheles gambiaeVoltage-gated sodium channel geneNatural insect populationsEvolution of resistanceInsecticide resistance mutationsIndependent mutation eventsGambiae S formSodium channel geneMalaria vector AnophelesKnockdown resistance alleleKnockdown resistance (kdr) mutationsGene flowMolecular evolutionNeutrality testsSelective sweepsMalaria vector control programmesAdaptive traitsMultiple mutation eventsInsect populationsGenomic regionsHaplotype compositionKdr locusLocal selection
1998
A Global Haplotype Analysis of the Myotonic Dystrophy Locus: Implications for the Evolution of Modern Humans and for the Origin of Myotonic Dystrophy Mutations
Tishkoff S, Goldman A, Calafell F, Speed W, Deinard A, Bonne-Tamir B, Kidd J, Pakstis A, Jenkins T, Kidd K. A Global Haplotype Analysis of the Myotonic Dystrophy Locus: Implications for the Evolution of Modern Humans and for the Origin of Myotonic Dystrophy Mutations. American Journal Of Human Genetics 1998, 62: 1389-1402. PMID: 9585589, PMCID: PMC1377140, DOI: 10.1086/301861.Peer-Reviewed Original ResearchConceptsNon-African populationsHaplotype diversityMyotonic dystrophy locusRecent African origin modelLinkage disequilibriumMyotonic dystrophy mutationModern human evolutionModern humansGlobal haplotype analysisMutation eventsStrong linkage disequilibriumNonhuman primate speciesPrimate speciesHuman evolutionHuman populationShared pattern
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