Reversion is most likely under high mutation supply when compensatory mutations do not fully restore fitness costs
Pennings P, Ogbunugafor C, Hershberg R. Reversion is most likely under high mutation supply when compensatory mutations do not fully restore fitness costs. G3: Genes, Genomes, Genetics 2022, 12: jkac190. PMID: 35920784, PMCID: PMC9434179, DOI: 10.1093/g3journal/jkac190.Peer-Reviewed Original ResearchConceptsCompensatory mutationsPopulation geneticsExperimental evolutionDynamics of adaptationMutation rateWild typeEvolution of antibiotic resistanceQuality of mutationsTheoretical population geneticsDynamics of compensationEvolution of mutationsMutation supplyMicrobial evolutionNonmutant strainsProbability of reversalMutated strainsEvolutionary dynamicsFitness costsAntibiotic resistanceFitness effectsMutationsAdaptive dynamicsGeneticsStrainPotential role
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