A Novel Canine Model of Immune Thrombocytopenia
LeVine D, Birkenheuer A, Brooks M, Nordone S, Bellinger D, Jones S, Fischer T, Esserman D, Oglesbee S, Key N. A Novel Canine Model of Immune Thrombocytopenia. Blood 2012, 120: 3326. DOI: 10.1182/blood.v120.21.3326.3326.Peer-Reviewed Original ResearchImmune thrombocytopeniaPlatelet countSimilar platelet countsD-dimerSerum IL8Canine modelHigh cumulative effective doseWhite blood cell countBuccal mucosal bleeding timeAdult research dogsHuman immune thrombocytopeniaSerum cytokine measurementsBlood cell countCumulative effective doseMucosal bleeding timeComplete blood countMurine IgG2a monoclonal antibodyDose-dependent thrombocytopeniaITP modelWilcoxon rank sum testLarge animal modelIgG2a monoclonal antibodyNovel canine modelRank sum testNeutrophil chemokines
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