Allosteric inhibition of the IZUMO1–JUNO fertilization complex by the naturally occurring antisperm antibody OBF13
Lu Y, Ikawa M, Tang S. Allosteric inhibition of the IZUMO1–JUNO fertilization complex by the naturally occurring antisperm antibody OBF13. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2425952122. PMID: 40042902, PMCID: PMC11912406, DOI: 10.1073/pnas.2425952122.Peer-Reviewed Original ResearchConceptsFour-helix domainAllosteric inhibitionBinding of acrosome-reacted spermAcrosome-reacted spermSperm-egg interactionDeep mutational scanningX-ray crystal structureMurine spermSingle-chain fragment variablesSperm IZUMO1IZUMO1Mutational scanningMammalian fertilizationApparent affinityHamster eggsMurine fertilizationSpecies-specificSpermMurine eggsAntisperm antibodiesFragment variablesConformational changesSomatic hypermutationAntispermLow levels of somatic hypermutation
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