2025
A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity
Fang Z, Monteiro V, Oh C, Janabi K, Romero L, Ahsan N, Yang L, Peng L, DiMaio D, Lucas C, Chen S. A modular vaccine platform for optimized lipid nanoparticle mRNA immunogenicity. Nature Biomedical Engineering 2025, 1-16. PMID: 40855125, DOI: 10.1038/s41551-025-01478-6.Peer-Reviewed Original ResearchModular vaccine platformCell surface translocationImmune responseMpox virusVaccine platformMRNA vaccinesVaricella zoster virus glycoproteinLethal viral challengeDevelopment of mRNA vaccinesInsufficient immune responseAntigen expressionProteins E6Surface expressionMRNA immunogenicityMultiple cell linesViral challengeAntigenMultiple antigensCell linesAntigenic epitopesChimeric antigenVirus glycoproteinImmunogenicityMRNASurface translocation
2024
Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
Malik S, Pradeep S, Kumar V, Xiao Y, Deng Y, Fan R, Vasquez J, Singh V, Bahal R. Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor. Cell Reports Medicine 2024, 5: 101354. PMID: 38183981, PMCID: PMC10829792, DOI: 10.1016/j.xcrm.2023.101354.Peer-Reviewed Original ResearchConceptsTarget genomic DNAGenomic DNASequencing of genomic DNAGenomic DNA levelInhibit c-myc transcriptionC-myc transcriptionGenomic DNA targetsTarget oncogenesMultiple cell linesC-Myc inhibitorCancer therapyHistone deacetylase inhibitorsRNA targetsDNA targetsPatient-derived xenograftsPre-clinical modelsDNADeacetylase inhibitorsCell linesOncogeneInhibiting oncogenesDNA levelsAntitumor efficacyPrecision medicineChemotherapeutic drugs
2022
Advances in Pigmentation Management: A Multipronged Approach.
Widgerow A, Wang J, Ziegler M, Fabi S, Garruto J, Robinson D, Bell M. Advances in Pigmentation Management: A Multipronged Approach. Journal Of Drugs In Dermatology 2022, 21: 1206-1220. PMID: 36342738, DOI: 10.36849/jdd.7013.Peer-Reviewed Original ResearchConceptsGene expression profilesCell linesExpression profilesProduction of pigmentsGene expression studiesMultiple cell linesProduction of melaninAffecting pigmentationPigment productionCellular pathwaysExpression studiesEndothelial cellsSynthesize melaninDistribute melaninMelanocyte linesIndependent pathwaysInhibitor of melanogenesisHuman skin pigmentationNeighboring keratinocytesCell typesHexapeptide-11Inflammation-related factorsGenesPathwayEndothelial cell interactions
2021
Olfactory receptor coding sequences cause silencing of episomal constructs in multiple cell lines
Abbas G, Tang S, Noble J, Lane R. Olfactory receptor coding sequences cause silencing of episomal constructs in multiple cell lines. Molecular And Cellular Neuroscience 2021, 117: 103681. PMID: 34742908, PMCID: PMC8669572, DOI: 10.1016/j.mcn.2021.103681.Peer-Reviewed Original Research In PressConceptsSensory neuronsOR expressionCell linesCoding sequenceOdorant receptorsOlfactory sensory neuronsReceptor coding sequenceMultiple cell linesMultiple odorant receptorsMammalian olfactory systemEpisomal constructsLevel of expressionTrans factorsComplex multi-step processOR genesBicistronic mRNAEpisomal expressionCMV promoterGFP geneReporter geneFibroblast cell lineOlfactory systemStable expressionGenesNeurons
2016
Genome-wide characterization of human L1 antisense promoter-driven transcripts
Criscione SW, Theodosakis N, Micevic G, Cornish TC, Burns KH, Neretti N, Rodić N. Genome-wide characterization of human L1 antisense promoter-driven transcripts. BMC Genomics 2016, 17: 463. PMID: 27301971, PMCID: PMC4908685, DOI: 10.1186/s12864-016-2800-5.Peer-Reviewed Original ResearchConceptsL1 antisense promoterAntisense promoterChimeric transcriptsHuman genomeGenome-wide characterizationGene transcriptional start siteHuman-specific subfamilyTranscriptional start siteYY1 transcription factorRNA-seq dataGenic transcriptsAntisense promoter activitySense promoterCellular transcriptomeMultiple cell linesHistone modificationsL1 biologyNeighboring genesTransposable elementsGenBank ESTsAntisense transcriptsHuman genesTranscription factorsStart siteActive promoters
2015
Use of Mechanistic Models to Integrate and Analyze Multiple Proteomic Datasets
Stites E, Aziz M, Creamer M, Von Hoff D, Posner R, Hlavacek W. Use of Mechanistic Models to Integrate and Analyze Multiple Proteomic Datasets. Biophysical Journal 2015, 108: 1819-1829. PMID: 25863072, PMCID: PMC4390817, DOI: 10.1016/j.bpj.2015.02.030.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorExperimentally detected interactionsPhosphotyrosine-binding domainSrc homology 2Recruitment of proteinsCell line-specific modelsProtein copy numbersProtein-protein interactionsCell signaling networksEpidermal growth factor receptor signalingCell linesWell-characterized roleCell line-specific differencesLow-affinity interactionsLine-specific differencesActivation of EGFR signalingMultiple cell linesLigand-stimulated activationAutophosphorylation sitesSignaling networksProteomic datasetsCopy numberHomolog 2EGFR SignalingMap interactions
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