Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment
Lv W, Zeng Y, Li C, Liang Y, Tao H, Zhu Y, Sui X, Li Y, Jiang S, Gao Q, Rodriguez-Fos E, Prasad G, Wang Y, Zhou R, Xu Z, Pan X, Chen L, Xiang X, Teng H, Sun C, Qin T, Dong W, Li Y, Lan X, Li X, Lin L, Bolund L, Yang H, Verhaak R, Faltas B, Hansen J, Wu S, Mischel P, Henssen A, Bafna V, Luebeck J, Regenberg B, Luo Y, Lin C, Han P. Spatial–Temporal Diversity of Extrachromosomal DNA Shapes Urothelial Carcinoma Evolution and the Tumor Immune Microenvironment. Cancer Discovery 2025, 15: 1225-1246. PMID: 40062518, PMCID: PMC12130809, DOI: 10.1158/2159-8290.cd-24-1532.Peer-Reviewed Original ResearchUrothelial carcinomaImmune microenvironmentWhole-genome sequencing dataExpression of major histocompatibility complex class I moleculesIncreased intratumoral heterogeneityTumor immune microenvironmentT cell immunityRecurrence of UCSamples of tumorHistocompatibility complex class I moleculesMajor histocompatibility complex class I moleculesSingle-cell RNA sequencing analysisMulti-region samplingRNA sequencing analysisClass I moleculesSequence dataUC tumorsExtrachromosomal DNAImmunosuppressive phenotypeSequence analysisT cellsClonal evolutionMalignant cellsPoor prognosisIntratumoral heterogeneity
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