2021
Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice
Lee SR, Thorn S, Guerrera N, Gonzalez L, Taniguchi R, Langford J, Sinusas AJ, Dardik A. Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice. JVS Vascular Science 2021, 2: 110-128. PMID: 34423320, PMCID: PMC8375600, DOI: 10.1016/j.jvssci.2021.05.002.Peer-Reviewed Original ResearchArteriovenous fistulaCardiac hypertrophyCardioprotective featuresRelative LV wall thicknessPoor cardiac outcomesRight heart functionSham-operated miceAdaptive cardiac hypertrophyLV wall thicknessSignificant sex-dependent differencesAreas of fibrosisInflammation-related genesPhysiologic cardiac hypertrophyCardiac chamber sizeCardiac fetal genesWild-type miceSex-dependent differencesSimilar body weightIngenuity Pathway AnalysisArrhythmogenic featuresAVF miceSerial echocardiographyCardiac outcomesDiastolic functionLV systolic
2020
Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction
Kim N, Ullah I, Chung K, Lee D, Cha MJ, Ban H, Choi CS, Kim S, Hwang KC, Kumar P, Lee SK. Targeted Delivery of Recombinant Heat Shock Protein 27 to Cardiomyocytes Promotes Recovery from Myocardial Infarction. Molecular Pharmaceutics 2020, 17: 2034-2043. PMID: 32364395, DOI: 10.1021/acs.molpharmaceut.0c00192.Peer-Reviewed Original ResearchConceptsAT1 receptor antibodyIschemic heart diseaseIschemia/reperfusionMyocardial infarctionMI ratsReceptor antibodiesHeart diseaseAngiotensin II type 1 receptorII type 1 receptorType 1 receptorAreas of fibrosisHeat shock protein 27Cause of deathRat MI modelShock protein 27Hypoxia-induced apoptosisIschemic injuryTherapeutic optionsCardiac functionProtective effectPromotes recoveryCardiomyocyte deathNormal responseMI modelSystemic delivery
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