2022
Oncometabolites as Regulators of DNA Damage Response and Repair
Gueble SE, Bindra RS. Oncometabolites as Regulators of DNA Damage Response and Repair. Seminars In Radiation Oncology 2022, 32: 82-94. PMID: 34861999, DOI: 10.1016/j.semradonc.2021.09.004.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDNA damage responseDamage responseDDR defectsMultiple DNA repair pathwaysSynthetic lethal interactionsDNA repair pathwaysRepair pathwaysLethal interactionsDiverse mechanismsOncometaboliteCancer therapyCertain cancersNew mechanismTherapeutic strategiesSmall intermediatesBiologyRegulatorPathwayMechanismRepairDDRMetabolismDysregulationDefectsResponse
2021
The activation mechanisms of master kinases in the DNA damage response
Xiao J, Rao Q, Xu Y. The activation mechanisms of master kinases in the DNA damage response. Genome Instability & Disease 2021, 2: 211-224. DOI: 10.1007/s42764-021-00045-y.Peer-Reviewed Original ResearchDNA damage responsePIKK regulatory domainDNA-PKDamage responseMultiple DNA repair pathwaysDNA damageStructures of ATMCryo-electron microscopyDNA repair pathwaysSeries of proteinsKinase structureMaster kinaseRegulatory domainRepair pathwaysGenetic informationCritical kinaseMolecular mechanismsSophisticated mechanismsExtrinsic stimuliActivation mechanismKinaseCritical roleATRPathwayEukaryotes
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