High Throughput Single-Cell Simultaneous Genotyping and Chromatin Accessibility Reveals Genotype to Phenotype Relationship in Human Myeloproliferation
Myers R, Izzo F, Prieto T, Mimitou E, Raviram R, Chaligne R, Hoffman R, Stahl M, Abdel-Wahab O, Marcellino B, Smibert P, Landau D. High Throughput Single-Cell Simultaneous Genotyping and Chromatin Accessibility Reveals Genotype to Phenotype Relationship in Human Myeloproliferation. Blood 2021, 138: 678. DOI: 10.1182/blood-2021-149226.Peer-Reviewed Original ResearchChromatin accessibilityMotif accessibilityFitness advantageTranscription factor (TFGenotype to phenotype relationshipsSomatic mutationsGenotype-to-phenotype mapCopy number inferenceChromatin accessibility profilesSingle-cell multi-omicsCell-type specific effectsPseudo-temporal orderingCell line identityTarget gene transcriptionTranscription factor activityMyeloproliferative neoplasmsJAK2 V617FCell fractionClonal outgrowthStages of erythroid maturationEntity's Board of DirectorsGenome coverageGenotyping accuracyGenomic locationsMPN samples
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