Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis
Kocan M, See H, Sampaio N, Eidne K, Feldman B, Pfleger K. Agonist-Independent Interactions between β-Arrestins and Mutant Vasopressin Type II Receptors Associated with Nephrogenic Syndrome of Inappropriate Antidiuresis. Endocrinology 2009, 23: 559-571. PMID: 19179480, PMCID: PMC2667710, DOI: 10.1210/me.2008-0321.Peer-Reviewed Original ResearchConceptsAssociated with impaired signalingSyndrome of inappropriate antidiuresisImpaired signalingArginine vasopressin levelsNephrogenic diabetes insipidusAgonist-independent internalizationSevere symptomatic hyponatremiaPlasma membraneV2R R137HType II receptorMutation-dependent differencesDynamin-dependent internalizationInappropriate antidiuresisNephrogenic syndromeArginine to histidineVasopressin type II receptorSymptomatic hyponatremiaDiabetes insipidusVasopressin levelsBioluminescence resonance energy transferMale infantG-protein uncouplingCodon 137II receptorsKidney's ability
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