Recommendations for Preclinical Testing of Treatments Against Alzheimer’s Disease-Related Epileptiform Spikes in Transgenic Rodent Models
Jin N, Babiloni C, Drinkenburg W, Hajós M, Nygaard H, Tanila H. Recommendations for Preclinical Testing of Treatments Against Alzheimer’s Disease-Related Epileptiform Spikes in Transgenic Rodent Models. Journal Of Alzheimer’s Disease 2022, 88: 849-865. PMID: 34092642, DOI: 10.3233/jad-210209.Peer-Reviewed Original ResearchConceptsTransgenic rodent modelsAlzheimer's diseaseRodent modelsPreclinical testingEEG spikesEpileptiform spikesAccelerated disease progressionDisease-modifying drugsRat AD modelClear unmet needSuitable animal modelDiagnosis of epilepsyAD pathologyEpileptiform activityAD patientsDisease progressionMultidisciplinary panelClinical valueDrug interventionAD modelAnimal modelsUnmet needModel rodentsAbnormal levelsDisease
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