Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail
Blott E, Bossi G, Clark R, Zvelebil M, Griffiths G. Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail. Journal Of Cell Science 2001, 114: 2405-2416. PMID: 11559749, DOI: 10.1242/jcs.114.13.2405.Peer-Reviewed Original ResearchConceptsProline-rich domainSecretory lysosomesPlasma membraneCytoplasmic tailSH3 domain-containing proteinsCell surface receptor FasFas ligandCell surface expression of FasLSH3-domain-containingSurface expression of FasLCell typesPositively charged residuesMis-sortingSorting motifDeletion mutantsExpression of FasLReceptor FasEndogenous FasLInduce apoptosisCharged residuesCell surface expressionLysosomal compartmentFasLLysosomesMotif
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