2015
DNA-repair defects in pancreatic neuroendocrine tumors and potential clinical applications
Liu IH, Ford JM, Kunz PL. DNA-repair defects in pancreatic neuroendocrine tumors and potential clinical applications. Cancer Treatment Reviews 2015, 44: 1-9. PMID: 26924193, DOI: 10.1016/j.ctrv.2015.11.006.Peer-Reviewed Original ResearchConceptsDNA repair pathwaysDNA repair defectsRepair pathwaysRepair genesRelevant DNA repair pathwaysPromoter hypermethylationDNA repair gene MGMTDNA repair processesDNA repair genesMMR genesTumor samplesDNA repairGene MGMTSpecific genesLoss of expressionUnderexpressed genesRepair defectsGenetic landscapeGenesMLH1 MMR geneDNA mismatch repair genesRepair mechanismsMGMT geneMismatch repair genesPTEN
1999
Different mutator phenotypes in Mlh1- versus Pms2-deficient mice
Yao X, Buermeyer A, Narayanan L, Tran D, Baker S, Prolla T, Glazer P, Liskay R, Arnheim N. Different mutator phenotypes in Mlh1- versus Pms2-deficient mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 6850-6855. PMID: 10359802, PMCID: PMC22005, DOI: 10.1073/pnas.96.12.6850.Peer-Reviewed Original ResearchConceptsMismatch repairMutator phenotypeMutation rateDifferent chromosomal locationsSingle-molecule PCRDinucleotide repeat lociMutation frequencyDNA mismatch repairMononucleotide repeat tractsChromosomal locationCellular processesDNA repair capacityHigh mutation frequencyDifferent mutator phenotypesMultiple genetic alterationsKnockout strainRepeat tractMlh1pMLH1 MMR geneRepeat lociGenetic alterationsDifferent tumor spectrumRepair capacityTumor developmentMMR genes
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