Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist
Cypess AM, Weiner LS, Roberts-Toler C, Elía E, Kessler SH, Kahn PA, English J, Chatman K, Trauger SA, Doria A, Kolodny GM. Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist. Cell Metabolism 2015, 21: 33-38. PMID: 25565203, PMCID: PMC4298351, DOI: 10.1016/j.cmet.2014.12.009.Peer-Reviewed Original ResearchConceptsBrown adipose tissueBAT metabolic activityΒ3-adrenergic receptor agonistΒ3-AR agonistPositron emission tomographyReceptor agonistComputed tomographyAdipose tissueEndogenous brown adipose tissueRodent brown adipose tissueHuman BAT thermogenesisHuman brown adipose tissueHealthy male subjectsKcal/dayOveractive bladderBAT thermogenesisPromising treatmentMetabolic diseasesMale subjectsMetabolic activityEmission tomographyAgonistsEnergy expenditureSignificant predictorsMirabegron
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