High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow
Bracko O, Vinarcsik L, Cruz Hernández J, Ruiz-Uribe N, Haft-Javaherian M, Falkenhain K, Ramanauskaite E, Ali M, Mohapatra A, Swallow M, Njiru B, Muse V, Michelucci P, Nishimura N, Schaffer C. High fat diet worsens Alzheimer’s disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow. Scientific Reports 2020, 10: 9884. PMID: 32555372, PMCID: PMC7303150, DOI: 10.1038/s41598-020-65908-y.Peer-Reviewed Original ResearchConceptsAPP/PS1 miceAlzheimer's diseaseAPP/PS1 genotypeMouse model of ADAmyloid-beta monomersAD-related pathologyModel of ADHigh-fat dietNeutrophil adhesionAPP/PS1Cerebral blood flowBlocking neutrophil adhesionCapillary stallingIncreased brain inflammationSeverity of Alzheimer's diseaseShort-term memory functionPoorer memory performanceImpaired social interactionSynergistic impairmentFat dietCerebral blood flow deficitsHFDGenotypesSensory-motor functionMemory performance
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