2024
The p. S178L mutation in Tbc1d24 disrupts endosome‐mediated synaptic vesicle trafficking of cochlear hair cells and leads to hearing impairment in mice
Chen P, Hou S, Li G, Lin Y, Lu J, Song L, Li G, Pang X, Wu H, Yang T. The p. S178L mutation in Tbc1d24 disrupts endosome‐mediated synaptic vesicle trafficking of cochlear hair cells and leads to hearing impairment in mice. Clinical Genetics 2024, 107: 67-77. PMID: 39400345, DOI: 10.1111/cge.14620.Peer-Reviewed Original ResearchNon-syndromic hearing lossSynaptic vesiclesRibbon synapses of cochlear inner hair cellsAutosomal dominant non-syndromic hearing lossDominant non-syndromic hearing lossEndosome-like vacuolesEndosomal membrane traffickingInner hair cellsSynaptic vesicle traffickingHearing lossRibbon synapsesHair cell ribbon synapsesKnock-in mouse modelMutant miceSustained exocytosisVesicle traffickingEndosomal traffickingMembrane traffickingVesicle recyclingIn vitro interactionCochlear inner hair cellsReduced exocytosisWave I amplitudeMild hearing lossAuditory brainstem response
2023
Diagnostic Accuracy of Mobile Health-Based Audiometry for the Screening of Hearing Loss in Adults: A Systematic Review and Meta-Analysis
Wang K, Wei W, Shi J, Qi B, Zhu Z, Li Z. Diagnostic Accuracy of Mobile Health-Based Audiometry for the Screening of Hearing Loss in Adults: A Systematic Review and Meta-Analysis. Telemedicine Journal And E-Health 2023, 29: 1433-1445. PMID: 36862527, DOI: 10.1089/tmj.2022.0427.Peer-Reviewed Original ResearchConceptsPure tone audiometryHearing loss screeningModerate hearing lossSpeech recognition testsHearing lossPure tone audiometry thresholdsScreening of hearing lossArea under the receiver operating characteristic curveAppraised methodological qualityMild hearing lossPrimary care sitesChronic health conditionsMeta-analysisDiagnostic accuracyPooled sensitivityTone audiometryRandom-effects modelCare sitesAudiometryMethodological qualitySRT testHealth conditionsLow-income regionsChinese databasesIn-person
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