Inactivation of pyridoxal phosphate dependent enzymes by mono- and polyhaloalanines.
Silverman R, Abeles R. Inactivation of pyridoxal phosphate dependent enzymes by mono- and polyhaloalanines. Biochemistry 1976, 15: 4718-23. PMID: 974085, DOI: 10.1021/bi00666a028.Peer-Reviewed Original ResearchConceptsPyridoxal phosphate dependent enzymesDependent enzymesGamma-elimination reactionActive siteAlanine racemaseGlutamate-pyruvateCovalent modificationMechanism of inactivationEnzymeEnzyme concentrationInactivationCovalent labelingSchiff base formationRate of inactivationPyridoxalGamma-cystathionaseBetaActivated Michael acceptorsBase formationMichael acceptorsMichael addition
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