Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism
Wu Q, Song D, Zhao Y, Verdegaal A, Turocy T, Duncan-Lowey B, Goodman A, Palm N, Crawford J. Activity of GPCR-targeted drugs influenced by human gut microbiota metabolism. Nature Chemistry 2025, 17: 808-821. PMID: 40181149, PMCID: PMC12412589, DOI: 10.1038/s41557-025-01789-w.Peer-Reviewed Original ResearchConceptsGut commensal bacteriaCommensal bacteriaGut microbial communityGut microbiota metabolismDrug metabolismMetabolize drugsMicrobial communitiesIndividual speciesMetabolic modeMorganella morganiiMicrobiota metabolismGPCR-targeted drugsTricyclic systemThiophene motifsBacteria mixtureBacteriaMetabolomics investigationsMetabolismTargeting GPCRsDrug metabolitesPharmacological efficacyDrug transformationDrug structureDrugMetabolites
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