2025
New thoughts on the intestinal microbiome-B cell-IgA axis and therapies in IgA nephropathy
Dang S, Zhang X, Zhang Y, Zhang H. New thoughts on the intestinal microbiome-B cell-IgA axis and therapies in IgA nephropathy. Autoimmunity Reviews 2025, 24: 103835. PMID: 40360014, DOI: 10.1016/j.autrev.2025.103835.Peer-Reviewed Original ResearchEnd-stage renal diseaseIgA nephropathyLack of effective early diagnosisPrognosis of patientsPathogenesis of IgANPathogenic IgAIntestinal flora dysbiosisImmune milieuMucosal infectionsEffective early diagnosisRetrospective reviewChronic glomerulonephritisRenal diseaseIgA depositionChronic progressionEarly diagnosisPathological featuresTherapeutic approachesPathogenic mechanismsIgANTherapeutic initiativesIgAIgA productionMesangial regionNephropathy
1985
Monoclonal antibody to Na,K-ATPase: Immunocytochemical localization along nephron segments
Kashgarian M, Biemesderfer D, Caplan M, Forbush B. Monoclonal antibody to Na,K-ATPase: Immunocytochemical localization along nephron segments. Kidney International 1985, 28: 899-913. PMID: 3003443, DOI: 10.1038/ki.1985.216.Peer-Reviewed Original ResearchConceptsMonoclonal antibodiesNephron segmentsEvidence of labellingRenal tubular epithelial cellsTubular epithelial cellsK-ATPaseThick ascending limbOnly principal cellsDifferent nephron segmentsDog antigensBasal-lateral membranesSignificant antibodiesAscending limbMesangial regionHenle's loopOccasional cellsRenal medullaOuter renal medullaAbundant antibodyAntibodiesApical labelingTubule segmentsPrincipal cellsEpithelial cellsImmunocytochemical localization
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