Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision
Abadie K, Clark E, Valanparambil R, Ukogu O, Yang W, Daza R, Ng K, Fathima J, Wang A, Lee J, Nasti T, Bhandoola A, Nourmohammad A, Ahmed R, Shendure J, Cao J, Kueh H. Reversible, tunable epigenetic silencing of TCF1 generates flexibility in the T cell memory decision. Immunity 2024, 57: 271-286.e13. PMID: 38301652, PMCID: PMC10922671, DOI: 10.1016/j.immuni.2023.12.006.Peer-Reviewed Original ResearchConceptsT cellsCD8<sup>+</sup> T cellsMemory T cell numbersT cell numbersOptimal immune responseImmune response magnitudeMemory potentialAcute infection modelResponse to stimulationImmune responseAntigen recognitionSelf-RenewalInfection modelPathogen clearanceMemory regulationCell numberEpigenetic silencingTCF1Response magnitudeCells
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