2015
The tethering of chromatin to the nuclear envelope supports nuclear mechanics
Schreiner SM, Koo PK, Zhao Y, Mochrie SG, King MC. The tethering of chromatin to the nuclear envelope supports nuclear mechanics. Nature Communications 2015, 6: 7159. PMID: 26074052, PMCID: PMC4490570, DOI: 10.1038/ncomms8159.Peer-Reviewed Original ResearchConceptsNuclear mechanicsRole of chromatinOptical tweezersWild-type nucleiNetwork of lipidsCytoskeletal forcesNuclear laminaCytoskeletal dynamicsMechanical defensesMembrane tethersDeformable nucleiNuclear envelopeChromatinNuclear shapeIsolated nucleiIndividual mechanical contributionsMembrane resultsNucleusTweezersMechanicsLaminsProteinTetheringLaminaDefense
2014
Coupling between endocytosis and sphingosine kinase 1 recruitment
Shen H, Giordano F, Wu Y, Chan J, Zhu C, Milosevic I, Wu X, Yao K, Chen B, Baumgart T, Sieburth D, De Camilli P. Coupling between endocytosis and sphingosine kinase 1 recruitment. Nature Cell Biology 2014, 16: 652-662. PMID: 24929359, PMCID: PMC4230894, DOI: 10.1038/ncb2987.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCaenorhabditisCell MembraneCells, CulturedChlorocebus aethiopsCholesterolCOS CellsEndocytosisFluorescent Antibody TechniqueHEK293 CellsHeLa CellsHumansMiceModels, MolecularMutationPhosphotransferases (Alcohol Group Acceptor)Protein BindingProtein Structure, TertiarySequence AnalysisConceptsSphingosine kinase 1Hydrophobic patchN-BAR proteinsEndocytic membrane trafficExo/endocytosisPlasma membrane resultsMembrane trafficEndocytic intermediatesFunction mutantsMembrane recruitmentEndocytic membranesCellular compartmentsIntercellular signalingRecycling defectsSphingosine phosphorylationKinase 1Genetic studiesFunctional linkTubular invaginationsSphingolipid metabolismLipid bilayersEndocytosisEnzyme surfaceMembrane resultsRecruitment
2005
Lipid segregation and IgE receptor signaling: A decade of progress
Holowka D, Gosse J, Hammond A, Han X, Sengupta P, Smith N, Wagenknecht-Wiesner A, Wu M, Young R, Baird B. Lipid segregation and IgE receptor signaling: A decade of progress. Biochimica Et Biophysica Acta 2005, 1746: 252-259. PMID: 16054713, DOI: 10.1016/j.bbamcr.2005.06.007.Peer-Reviewed Original ResearchConceptsLipid raftsReceptor phosphorylationSrc family kinase LynTransmembrane tyrosine phosphataseLipid segregationPlasma membrane resultsIgE receptor signalingCell surface receptorsActive LynKinase LynTyrosine phosphataseCytoskeletal interactionsSignal transductionRaft environmentMembrane skeletonDisordered regionsReceptor signalingSurface receptorsSegregation of liquidIgE receptorMembrane structureLynPhosphorylationMembrane resultsComplex role
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