Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes
Wong W, Lowery M, Berger M, Kemel Y, Taylor B, Zehir A, Srinivasan P, Bandlamudi C, Chou J, Capanu M, Varghese A, Yu K, Iacobuzio‐Donahue C, Shia J, Klimstra D, Jarnagin W, Stadler Z, O’Reilly E. Ampullary cancer: Evaluation of somatic and germline genetic alterations and association with clinical outcomes. Cancer 2019, 125: 1441-1448. PMID: 30620386, PMCID: PMC6467723, DOI: 10.1002/cncr.31951.Peer-Reviewed Original ResearchConceptsPathogenic germline alterationsAmpullary carcinomaSomatic alterationsGermline testingSomatic testingMemorial Sloan Kettering Integrated Mutation Profiling of Actionable Cancer TargetsMemorial Sloan Kettering Cancer CenterDe-identified fashionMedian overall survivalPartial radiographic responseRare gastrointestinal cancerTargetable somatic alterationsGermline genetic alterationsSubtypes of ACOpt-in strategyRadiographic responseOverall survivalMSK-IMPACTClinicopathological featuresGermline alterationsClinical outcomesPathological subtypesGenetic alterationsClinical correlatesGastrointestinal cancer
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