PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia
Konttinen H, Cabral-da-Silva M, Ohtonen S, Wojciechowski S, Shakirzyanova A, Caligola S, Giugno R, Ishchenko Y, Hernández D, Fazaludeen M, Eamen S, Budia M, Fagerlund I, Scoyni F, Korhonen P, Huber N, Haapasalo A, Hewitt A, Vickers J, Smith G, Oksanen M, Graff C, Kanninen K, Lehtonen S, Propson N, Schwartz M, Pébay A, Koistinaho J, Ooi L, Malm T. PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia. Stem Cell Reports 2019, 13: 669-683. PMID: 31522977, PMCID: PMC6829767, DOI: 10.1016/j.stemcr.2019.08.004.Peer-Reviewed Original ResearchConceptsInduced pluripotent stem cellsPluripotent stem cellsErythromyeloid progenitorsDisparate phenotypesIsogenic controlsSignature genesMicroglia-like cellsHuman microglia-like cellsGenetic backgroundHuman iPSCStem cellsMicroglial signature genesYolk sacIPSC linesIntracellular CaImpairs phagocytosisIMGLsMetabolic activitySmall moleculesHigh-yield protocolCellsAPPswe mutationMinor alterationsCytokine secretionGenes
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