2023
Quantifying the impact of immunotherapy on RNA dynamics in cancer
Usaite I, Biswas D, Dijkstra K, Watkins T, Pich O, Puttick C, Angelova M, Thakkar K, Hiley C, Birkbak N, Kok M, Zaccaria S, Wu Y, Litchfield K, Swanton C, Kanu N. Quantifying the impact of immunotherapy on RNA dynamics in cancer. Journal For ImmunoTherapy Of Cancer 2023, 11: e007870. PMID: 37914385, PMCID: PMC10626770, DOI: 10.1136/jitc-2023-007870.Peer-Reviewed Original ResearchConceptsCheckpoint inhibitorsCheckpoint inhibitor treatmentBreast cancerOn-therapyImmune microenvironmentPre-therapyCancer typesPatients treated with checkpoint inhibitorsCheckpoint inhibitor therapyImpact of immunotherapyCancer immune microenvironmentSolid tumor typesMechanism of sensitizationClinical responseCombination therapyTumor typesIO targetsResponse ratePatientsBreastCancerImmunotherapyMelanomaMeta-analysesTherapy
2021
Polyisocyanates and Their Prepolymers
Jolly A, Maestrelli P, Redlich C, Malo J, Bernstein D. Polyisocyanates and Their Prepolymers. 2021, 179-194. DOI: 10.1201/9781003000624-14.ChaptersOccupational asthmaHuman leukocyte antigenAirway inflammationDiisocyanate-induced occupational asthmaSensitizer-induced occupational asthmaWeight agentsOnset of asthmaOnset of symptomsLong-term outcomesMedical surveillance programNon-HLA genesReduction of exposureAverage exposure levelsAirway hyperresponsivenessSevere asthmaAsthmatic symptomsClinical presentationNeutrophilic infiltrateLeukocyte antigenClinical assessmentDifferent exposure metricsIrritant concentrationsHigh riskMechanism of sensitizationIsocyanate exposure
2003
Alcohol and Zymogen Activation in the Pancreatic Acinar Cell
Gorelick FS. Alcohol and Zymogen Activation in the Pancreatic Acinar Cell. Pancreas 2003, 27: 305-310. PMID: 14576492, DOI: 10.1097/00006676-200311000-00006.Peer-Reviewed Original ResearchConceptsPancreatic acinar cellsAcinar cellsSupraphysiologic concentrationsAcute pancreatitisAbility of alcoholMechanism of sensitizationEarly featureIsolated aciniCholecystokininPancreatic aciniInduced activationSensitizationPancreatitisAciniZymogen activationActivationLysosomal markersGranule compartmentCellsActivation of zymogens
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