2025
TP53 genomic alterations including targetable TP53 Y220C mutation in clinically advanced breast cancer.
Casasanta N, Kahn A, Fischbach N, Pavlick D, Lustberg M, LoRusso P, Sokol E, Graf R, Quintanilha J, Li G, Levy M, Elvin J, Ross J, Pusztai L. TP53 genomic alterations including targetable TP53 Y220C mutation in clinically advanced breast cancer. Journal Of Clinical Oncology 2025, 43: 1043-1043. DOI: 10.1200/jco.2025.43.16_suppl.1043.Peer-Reviewed Original ResearchClinically advanced breast cancerTumor mutational burdenAdvanced breast cancerAssociated with GAGenomic alterationsWT groupTP53 WTBreast cancerMedian tumor mutation burdenTP53 genomic alterationsTP53 mutant groupPD-L1 expressionTP53 wild typeY220C mutationHomologous recombination deficiency signatureFisher's exact testMSI-highTumor suppressor geneAfrican genetic ancestryMedian GAPD-L1CDH1 mutationsLobular carcinomaMutational burdenEndocrine resistance
2024
Urinary Tract Infection and Progression to Pyelonephritis: Group B Streptococcus versus E. coli
Sachdeva S, Rosett H, Krischak M, Weaver K, Heine R, Denoble A, Dotters-Katz S. Urinary Tract Infection and Progression to Pyelonephritis: Group B Streptococcus versus E. coli. American Journal Of Perinatology Reports 2024, 14: e80-e84. PMID: 38370326, PMCID: PMC10874690, DOI: 10.1055/s-0044-1779031.Peer-Reviewed Original ResearchLower urinary tract infectionsLow birth weightUrinary tract infectionHistory of ACLength of stayPreterm deliveryGestational agePreterm birthTract infectionsPregnant womenRetrospective cohort of pregnant womenGroup B <i>Streptococcus</i> (GBPrimary outcomeHistory of preterm birthMedical records of womenCohort of pregnant womenLow birth weight rateAssociated with severe infectionsMedian gestational ageMedian length of stayGroup B streptococciLower urinary tractRecords of womenPrimary infection typeMedian GA
2021
Prediction Model Assessing Risk of Delivery after Diagnosis of Abnormal Umbilical Artery Doppler
Yu H, Has P, Danilack V, Werner E, Rouse D. Prediction Model Assessing Risk of Delivery after Diagnosis of Abnormal Umbilical Artery Doppler. American Journal Of Perinatology 2021, 40: 1253-1258. PMID: 34450676, DOI: 10.1055/s-0041-1735222.Peer-Reviewed Original ResearchConceptsFetal growth restrictionRisk of deliveryAntenatal corticosteroidsAbnormal UADAbnormal umbilical artery DopplerInitial eligibilityBackward stepwise logistic regressionDoppler velocimetry abnormalitiesInternal validationPre-pregnancy BMIReferral center studyUmbilical artery DopplerPrediction of deliveryRisk stratification methodsStepwise logistic regressionAntepartum managementArtery DopplerNeonatal morbiditySingleton pregnanciesCenter studyMedian GAGrowth restrictionMultivariable modelPatientsClinical aid
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