2024
Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons
Alexander T, Tymanskyj S, Kennedy K, Kaczmarek L, Covarrubias M. Molecular mechanism governing the plasticity of use-dependent spike broadening in dorsal root ganglion neurons. Proceedings Of The National Academy Of Sciences Of The United States Of America 2024, 122: e2411033121. PMID: 39739796, PMCID: PMC11725888, DOI: 10.1073/pnas.2411033121.Peer-Reviewed Original ResearchConceptsN-terminal inactivation domainDorsal root ganglionDorsal root ganglion neuronsSpike broadeningCumulative inactivationVoltage-gated K<sup>+</sup>Rat dorsal root ganglionViral vector approachPain modulationRoot ganglionGanglion neuronsKv3.4AP widthAction potentialsDynamic clampMechanosensory transductionInactivation domainNeuronsMolecular mechanismsFast recoveryInactivationSlow recoveryPhosphorylationPainRepolarization
2014
Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes*
Bagriantsev SN, Gracheva EO, Gallagher PG. Piezo Proteins: Regulators of Mechanosensation and Other Cellular Processes*. Journal Of Biological Chemistry 2014, 289: 31673-31681. PMID: 25305018, PMCID: PMC4231648, DOI: 10.1074/jbc.r114.612697.Peer-Reviewed Original ResearchConceptsPiezo proteinsCellular processesMammalian cellsCellular developmentMechanosensory transductionCellular migrationIon channelsHereditary xerocytosisVolume regulationProteinBiologic processesRegulationImportant insightsTransductionMechanosensationRegulatorMutationsXerocytosisProliferationCellsMechanoVariety of disordersElongationMigrationProminent feature
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply