Self-compassion mediates treatment effects in MDMA-assisted therapy for posttraumatic stress disorder
Agin-Liebes G, Zeifman R, Mitchell J. Self-compassion mediates treatment effects in MDMA-assisted therapy for posttraumatic stress disorder. European Journal Of Psychotraumatology 2025, 16: 2485513. PMID: 40331914, PMCID: PMC12064107, DOI: 10.1080/20008066.2025.2485513.Peer-Reviewed Original ResearchConceptsMDMA-assisted therapyPosttraumatic stress disorderUncompassionate self-respondingCompassionate self-respondingSevere posttraumatic stress disorderReducing PTSD severitySelf-CompassionPTSD severityStress disorderSelf-kindnessSelf-judgmentDepressive symptomsOver-identificationMeasures of PTSD severitySelf-respondentsCo-occurring disordersSubstance use symptomsSelf-Compassion ScaleCo-occurring depressionAlcohol use disorderSubstance use disordersUse disorderDouble-blind trialPlacebo-controlled trialPsychological mechanisms
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