2021
Biocompatibility of platinum-based bulk metallic glass in orthopedic applications
Loye AM, Kwon HK, Dellal D, Ojeda R, Lee S, Davis R, Nagle N, Doukas PG, Schroers J, Lee FY, Kyriakides TR. Biocompatibility of platinum-based bulk metallic glass in orthopedic applications. Biomedical Materials 2021, 16: 045018. PMID: 33873168, DOI: 10.1088/1748-605x/abf981.Peer-Reviewed Original ResearchConceptsBulk metallic glassPt-BMGPlatinum-based bulk metallic glassMetallic glassesConventional metallic implantsCorrosion resistanceHigh strengthMechanical testingOrthopedic applicationsBone applicationsMetallic implantsMicro-computed tomographyAmorphous metalsTitaniumWearBiocompatibilitySimilar biocompatibilityFurther processingGlassDuctilityNanopatternsNanoscaleApplicationsMesenchymal stem cellsStrengthFinite Element Analysis of Cannulated Screws as Prophylactic Intervention of Hip Fractures
Rhee B, Tommasini SM, Milligan K, Moulton J, Leslie M, Wiznia DH. Finite Element Analysis of Cannulated Screws as Prophylactic Intervention of Hip Fractures. Geriatric Orthopaedic Surgery & Rehabilitation 2021, 12: 21514593211055890. PMID: 34868723, PMCID: PMC8637371, DOI: 10.1177/21514593211055890.Peer-Reviewed Original ResearchLinear finite element simulationsOsteoporotic proximal femurFinite element simulationsPeak von Mises stressFinite element analysisFinite element modelVon Mises stressCannulated screwsProximal femurHip fractureGeriatric patientsLateral fallElement simulationsElement modelMises stressElement analysisMechanical testingCannulated hip screwsFemoral neck fracturesTrabecular failureComputed tomography scanElement failureSingle-leg stanceTriangle formationNeck fractures
2018
Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds
Morris AH, Stamer DK, Kunkemoeller B, Chang J, Xing H, Kyriakides TR. Decellularized materials derived from TSP2-KO mice promote enhanced neovascularization and integration in diabetic wounds. Biomaterials 2018, 169: 61-71. PMID: 29631168, PMCID: PMC5933884, DOI: 10.1016/j.biomaterials.2018.03.049.Peer-Reviewed Original ResearchConceptsUltimate tensile strengthECM-based materialsTensile strengthMechanical testingDecellularized materialsElastic modulusSynthetic biomaterialsIntact slabsMatrix propertiesExtracellular matrix propertiesCell-derived ECMBiologic scaffoldsElectron microscopyEngineering controlsMaterialsWtEfficient integrationEnhanced vascularizationModulusPromigratory propertiesScaffoldsPropertiesBiomaterialsEnhanced remodelingGreater cell migration
2010
Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement
Nerurkar NL, Sen S, Huang AH, Elliott DM, Mauck RL. Engineered Disc-Like Angle-Ply Structures for Intervertebral Disc Replacement. Spine 2010, 35: 867-873. PMID: 20354467, PMCID: PMC3421837, DOI: 10.1097/brs.0b013e3181d74414.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsBiomechanical PhenomenaCattleCells, CulturedCompressive StrengthExtracellular MatrixFibrocartilageHumansHydrogelsIntervertebral DiscIntervertebral Disc DisplacementMaterials TestingMesenchymal Stem Cell TransplantationMesenchymal Stem CellsNanofibersProsthesis DesignSepharoseTissue EngineeringTissue ScaffoldsWeight-Bearing
2007
Biaxial Mechanics of Musculoskeletal Tissue and Fiber-Reinforced Scaffolds
O’Connell G, Sen S, Baker B, Mauck R, Elliott D. Biaxial Mechanics of Musculoskeletal Tissue and Fiber-Reinforced Scaffolds. 2007, 935-936. DOI: 10.1115/sbc2007-176540.Peer-Reviewed Original ResearchUniaxial testsFiber-reinforced tissuesBiaxial tensile testingBiaxial mechanical testingLarge aspect ratioBiaxial experimentsTensile testingBiaxial testsUniaxial behaviorMechanical testingBiaxial behaviorAspect ratioSitu geometryStrain configurationBoundary conditionsMusculoskeletal tissuesPrimary experimentsModel parametersLarge domainsBehaviorTest
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