When activated oncogene meets immunity: A fight to prevent liver tumor initiation
Nault J, Amaddeo G, Zucman-Rossi J, Groszmann R, Iwakiri Y, Taddei T. When activated oncogene meets immunity: A fight to prevent liver tumor initiation. Hepatology 2012, 56: 387-389. PMID: 22876365, DOI: 10.1002/hep.25733.Peer-Reviewed Original ResearchCellular senescence programHepatocellular carcinomaOncogene-induced senescenceSenescence surveillanceMurine hepatocytes in vivoT cell-mediated adaptive immune responseImmune responseCD4(+) T cellsTumor suppression in vivoTumor immune surveillanceMount specific immune responsesSenescent hepatocytesImpaired immune surveillanceMurine hepatocellular carcinomaImmune-mediated clearanceTumor development in vivoSecrete various cytokinesSpecific immune responsesAdaptive immune responsesAnti-tumorigenic effectsAnti-tumor barrierSuppression in vivoActivation of oncogenesStable cell cycle arrestSenescent cells
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