2011
Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems
Stinchcombe J, Salio M, Cerundolo V, Pende D, Arico M, Griffiths G. Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems. BMC Biology 2011, 9: 45. PMID: 21711522, PMCID: PMC3149597, DOI: 10.1186/1741-7007-9-45.Peer-Reviewed Original ResearchConceptsSecretory lysosomesINKT cellsCytotoxic T lymphocytesImmunological synapsePlasma membraneExocytosis of secretory lysosomesNatural killerCytolytic cellsAdaptive immune systemPore-forming protein perforinImmune systemThin-section electron microscopyEndocytic organellesRecycling endosomesGolgi apparatusTarget cellsLysosomal deliveryPathogen-infected cellsInnate immune systemLysosomal releaseCentrosomeB cell targetsINKTTarget cell recognitionLysosomes
2006
Regulating Secretory Lysosomes
Holt O, Gallo F, Griffiths G. Regulating Secretory Lysosomes. The Journal Of Biochemistry 2006, 140: 7-12. PMID: 16877763, DOI: 10.1093/jb/mvj126.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Protein Complex 3Alkyl and Aryl TransferasesAnimalsChediak-Higashi SyndromeHermanski-Pudlak SyndromeHumansLysosomesMembrane FusionMembrane ProteinsNerve Tissue Proteinsrab GTP-Binding Proteinsrab27 GTP-Binding ProteinsSNARE ProteinsT-Lymphocytes, CytotoxicVesicular Transport Proteins
2001
Normal and abnormal secretion by haemopoietic cells
Stinchcombe J, Griffiths G. Normal and abnormal secretion by haemopoietic cells. Immunology 2001, 103: 10-16. PMID: 11380687, PMCID: PMC1783215, DOI: 10.1046/j.1365-2567.2001.01225.x.Peer-Reviewed Original ResearchConceptsSecretory lysosomesSecretion of lysosomesSecretory cell typesEffector proteinsResponse to antigen recognitionCytoskeletal elementsHaemopoietic cellsImmunological synapseSpecialized secretionSpecialized granulesSecretory processCell typesLysosomesExcellent modelLysosomal releaseHaemopoietic lineagesCellsAntigen recognitionSecretionT lymphocytesImmune cellsSynapseTalinAbnormal secretionRab
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