2021
Dormant spores sense amino acids through the B subunits of their germination receptors
Artzi L, Alon A, Brock K, Green A, Tam A, Ramírez-Guadiana F, Marks D, Kruse A, Rudner D. Dormant spores sense amino acids through the B subunits of their germination receptors. Nature Communications 2021, 12: 6842. PMID: 34824238, PMCID: PMC8617281, DOI: 10.1038/s41467-021-27235-2.Peer-Reviewed Original ResearchConceptsAmino acid-polyamine-organocation superfamilyEvolutionary co-variation analysisL-alanine recognitionB subunitStress-resistant sporesSuperfamily of transportersPutative membrane receptorL-alanineResponse to L-alanineGerABNutrient sensingBacillus subtilisGerminant receptorsBulky residuesAmino acidsMembrane receptorsPrototypic receptorNutrient detectionSporesGerminationCo-variance analysisL-serineMutationsL-leucineBacillales
1999
Purification of serine racemase: Biosynthesis of the neuromodulator d-serine
Wolosker H, Sheth K, Takahashi M, Mothet J, Brady R, Ferris C, Snyder S. Purification of serine racemase: Biosynthesis of the neuromodulator d-serine. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 721-725. PMID: 9892700, PMCID: PMC15203, DOI: 10.1073/pnas.96.2.721.Peer-Reviewed Original ResearchConceptsBiosynthetic pathwayD-serine occursSerine racemaseAmino acidsD-serineMammalian brainNeuromodulator D-serineL-serineMolecular massSoluble enzymeEndogenous ligandPyridoxal phosphateRat brainN-methyl-D-aspartate receptorsEnzymeKm valuesRacemasePathwayHigh levelsRat cerebral cortexAspartate glutamate receptorsGlutamate receptorsRacemasesType II astrocytesGlial cultures
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