2019
NLRP3 Inflammasome regulation of lipolysis in aged adipose tissue
Camell C, Dixit V. NLRP3 Inflammasome regulation of lipolysis in aged adipose tissue. The FASEB Journal 2019, 33: 78.2-78.2. DOI: 10.1096/fasebj.2019.33.1_supplement.78.2.Peer-Reviewed Original ResearchAdipose tissue macrophagesAge-related reductionAdipose triglyceride lipaseHormone-sensitive lipaseVisceral adiposityFree fatty acidsAdipose tissueNLRP3 inflammasome-dependent mannerDeletion of NLRP3Inflammasome-dependent mannerTissue NE concentrationLower exercise capacityAge-related inflammationSympathetic nervous systemDiet-induced obesityImmune-metabolic interactionsCatecholamine-induced lipolysisWhite adipose tissueFull-text articlesCore body temperatureExercise capacityKey lipolytic enzymeMetabolic dysfunctionFunctional declineLeukocyte alterations
2011
Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity
Machado R, Barst R, Yovetich N, Hassell K, Kato G, Gordeuk V, Gibbs J, Little J, Schraufnagel D, Krishnamurti L, Girgis R, Morris C, Rosenzweig E, Badesch D, Lanzkron S, Onyekwere O, Castro O, Sachdev V, Waclawiw M, Woolson R, Goldsmith J, Gladwin M, Investigators and Patients O. Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity. Blood 2011, 118: 855-864. PMID: 21527519, PMCID: PMC3148167, DOI: 10.1182/blood-2010-09-306167.Peer-Reviewed Original ResearchConceptsTricuspid regurgitation velocitySickle cell diseaseLower exercise capacityExercise capacityCell diseaseN-terminal pro-brain natriuretic peptideElevated tricuspid regurgitation velocityPro-brain natriuretic peptideSerious adverse eventsPulmonary arterial hypertensionSildenafil trialArterial hypertensionAdverse eventsWalk distanceDoppler echocardiographySCD patientsHospitalization ratesNatriuretic peptidePatientsSildenafilPredominant causePainHospitalizationTreatment effectsDisease
1997
Relevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri.
Jain D, Thompson B, Wackers F, Zaret B, Investigators F. Relevance of Increased Lung Thallium Uptake on Stress Imaging in Patients With Unstable Angina and Non-Q Wave Myocardial Infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI)-IIIB Study fn1fn1This study was supported in part by a research grant from Mallinckrodt Medical Inc., Saint Louis, Missouri. Journal Of The American College Of Cardiology 1997, 30: 421-429. PMID: 9247514, DOI: 10.1016/s0735-1097(97)00164-2.Peer-Reviewed Original ResearchConceptsLung/heart ratioAdverse cardiac eventsNon-Q-wave myocardial infarctionCoronary artery diseaseCardiac eventsPerfusion abnormalitiesMyocardial infarctionUnstable anginaArtery diseaseStress-induced left ventricular dysfunctionHigher cardiac event rateLeft ventricular ejection fractionAggressive interventional managementHigher revascularization rateLung thallium uptakeCardiac event rateTotal exercise timeFrequency of anginaLeft ventricular dysfunctionST-segment depressionLower exercise capacityVentricular ejection fractionPrevious myocardial infarctionMyocardial perfusion abnormalitiesNormal myocardial perfusion
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