MicroRNAs organize intrinsic variation into stem cell states
Chakraborty M, Hu S, Visness E, Del Giudice M, De Martino A, Bosia C, Sharp P, Garg S. MicroRNAs organize intrinsic variation into stem cell states. Proceedings Of The National Academy Of Sciences Of The United States Of America 2020, 117: 6942-6950. PMID: 32139605, PMCID: PMC7104302, DOI: 10.1073/pnas.1920695117.Peer-Reviewed Original ResearchConceptsGene expression statesGene regulatory networksCell statesRegulatory networksEmbryonic stem cellsExpression statesAbsence of external gradientsPromoter state transitionsDevelopmental gene expression programsDiverse array of cellsGene expression programsStem cell stateLoss of miRNAsMorphogen gradientsEnvironmental signalsPluripotent embryonic stem cellsTarget genesGenesExpression programsAdult vertebratesPluripotency genesDiverse arrayExternal gradientDistinct activitiesVariable miRNAs
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