2021
SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation
Jarlhelt I, Nielsen S, Jahn C, Hansen C, Pérez-Alós L, Rosbjerg A, Bayarri-Olmos R, Skjoedt M, Garred P. SARS-CoV-2 Antibodies Mediate Complement and Cellular Driven Inflammation. Frontiers In Immunology 2021, 12: 767981. PMID: 34804055, PMCID: PMC8596567, DOI: 10.3389/fimmu.2021.767981.Peer-Reviewed Original ResearchConceptsSARS-CoV-2-specific antibodiesSARS-CoV-2 receptor-binding domainReceptor-binding domainComplement activationAntibody responseInflammatory responseSARS-CoV-2 antibody responseDisease severitySevere acute respiratory syndrome coronavirus 2Fc gamma receptor engagementAcute respiratory syndrome coronavirus 2COVID-19 disease severitySARS-CoV-2 antibodiesSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Pro-inflammatory cytokines TNFAntibody-mediated complement activationProminent complement activationSpecific antibodiesSyndrome coronavirus 2COVID-19 severitySerious public health threatCoronavirus disease 2019Classical complement pathway activationClassical complement activation
2019
Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ–Primed Human Endothelium
Xie CB, Qin L, Li G, Fang C, Kirkiles-Smith NC, Tellides G, Pober JS, Jane-Wit D. Complement Membrane Attack Complexes Assemble NLRP3 Inflammasomes Triggering IL-1 Activation of IFN-γ–Primed Human Endothelium. Circulation Research 2019, 124: 1747-1759. PMID: 31170059, PMCID: PMC6557295, DOI: 10.1161/circresaha.119.314845.Peer-Reviewed Original ResearchConceptsMembrane attack complexEndothelial cellsComplement membrane attack complexIL-1βNLRP3 inflammasomeEC immunogenicityComplement activationAntibody-mediated complement activationInflammasome assemblyComplement-mediated pathologiesRenal allograft biopsiesGraft endothelial cellsHuman coronary artery graftsLate allograft failureCoronary artery graftsT cell responsesImmune-mediated pathologyActivate endothelial cellsIL-1 receptorIL-1 synthesisIL-1β secretionNoncanonical NF-κB signalingNF-κB signalingAttack complexImmunodeficient mouse hosts
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