The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library.
Bunin B, Plunkett M, Ellman J. The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library. Proceedings Of The National Academy Of Sciences Of The United States Of America 1994, 91: 4708-4712. PMID: 8197123, PMCID: PMC43857, DOI: 10.1073/pnas.91.11.4708.Peer-Reviewed Original ResearchConceptsLarge-scale synthesisLibrary of derivativesChemical functionalityBenzodiazepine derivativesCombinatorial synthesisChemical integrityBiological evaluationCarboxylic acidsActivity relationshipsDiverse derivativesDerivativesSynthesisDetailed structureAcidAminesRadio-ligand binding assayAmidesAmino acidsIndolePhenolBinding assaysChemicalsYieldStructure
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