2023
TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses
Park E, Jeon H, Lee N, Yu J, Park H, Satoh T, Akira S, Furuyama T, Lee C, Choi J, Rho J. TDAG51 promotes transcription factor FoxO1 activity during LPS‐induced inflammatory responses. The EMBO Journal 2023, 42: embj2022111867. PMID: 37203866, PMCID: PMC10308371, DOI: 10.15252/embj.2022111867.Peer-Reviewed Original ResearchConceptsBone marrow-derived macrophagesInflammatory mediator productionInflammatory responseMediator productionTranscription factor FOXO1Lethal shockLPS-induced inflammatory responseSerum proinflammatory cytokine levelsToll-like receptor (TLR)-mediated inflammatory responsesFoxO1 activitySystemic inflammatory responseProinflammatory cytokine levelsMarrow-derived macrophagesTLR2/4 signaling pathwayFoxO1 nuclear accumulationT cellsCytokine levelsLipopolysaccharide (LPS)-induced inflammatory responsesTDAG51 deficiencyDouble deficiencyLPS-induced inflammatory mediator productionLPS stimulationInnate immunityCytoplasmic translocationLPS
2002
Staphylococcal enterotoxin B‐induced activation and concomitant resistance to cell death in CD28‐deficient HLA‐DQ8 transgenic mice
Rajagopalan G, Smart M, Marietta E, David C. Staphylococcal enterotoxin B‐induced activation and concomitant resistance to cell death in CD28‐deficient HLA‐DQ8 transgenic mice. International Immunology 2002, 14: 801-812. PMID: 12096040, DOI: 10.1093/intimm/dxf047.Peer-Reviewed Original ResearchConceptsT cellsStaphylococcal enterotoxin BHLA-DQ8IFN-gammaTransgenic miceEnterotoxin BBALB/c splenocytesDQ8 transgenic miceSerum IFN-gammaLess IL-2IL-6 productionAbsence of CD28Role of CD28Activation-induced cell deathCertain effector functionsIL-10Lethal shockIL-2IL-4Immune responseEffector functionsConcomitant resistanceCD28Nitric oxideMice
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply