2017
Let-7a regulates expression of β 1 -adrenoceptors and forms a negative feedback circuit with the β 1 -adrenoceptor signaling pathway in chronic ischemic heart failure
Du Y, Zhang M, Zhao W, Shu Y, Gao M, Zhuang Y, Yang T, Mu W, Li T, Li X, Sun F, Pan Z, Lu Y. Let-7a regulates expression of β 1 -adrenoceptors and forms a negative feedback circuit with the β 1 -adrenoceptor signaling pathway in chronic ischemic heart failure. Oncotarget 2017, 5: 8752-8764. PMID: 28060734, PMCID: PMC5352438, DOI: 10.18632/oncotarget.14436.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAnimalsBinding SitesCells, CulturedCyclic AMPCyclic AMP-Dependent Protein KinasesDisease Models, AnimalFeedback, PhysiologicalGATA4 Transcription FactorGene Expression RegulationHeart FailureMaleMicroRNAsMyocardial IschemiaMyocytes, CardiacOligonucleotides, AntisenseRats, Sprague-DawleyReceptors, Adrenergic, beta-1Signal TransductionTransfectionConceptsNeonatal rat ventricular cellsIschemic heart failureHeart failureChronic ischemic heart failureSignaling pathwayDown-regulationRat ventricular cellsCAMP-PKA signaling pathwayEarly phase of ischemiaOcclusion of coronary arteriesPhase of ischemiaVentricular cellsLentivirus vectorMyocardial ischemiaCoronary arteryMyocardial infarctionCAMP-PKALet-7aLet-7a expressionNegative feedback loopUp-regulatedGATA4IschemiaEarly phaseExpression
2014
let‐7e replacement yields potent anti‐arrhythmic efficacy via targeting beta 1‐adrenergic receptor in rat heart
Li X, Wang B, Cui H, Du Y, Song Y, Yang L, Zhang Q, Sun F, Luo D, Xu C, Chu W, Lu Y, Yang B. let‐7e replacement yields potent anti‐arrhythmic efficacy via targeting beta 1‐adrenergic receptor in rat heart. Journal Of Cellular And Molecular Medicine 2014, 18: 1334-1343. PMID: 24758696, PMCID: PMC4124018, DOI: 10.1111/jcmm.12288.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated RegionsAnimalsAnti-Arrhythmia AgentsArrhythmias, CardiacBiomarkersBlotting, WesternCells, CulturedGene Expression ProfilingGene Expression RegulationHeart RateMaleMicroRNAsMyocardial InfarctionMyocytes, CardiacRatsRats, WistarReal-Time Polymerase Chain ReactionReceptors, Adrenergic, beta-1Reverse Transcriptase Polymerase Chain ReactionRNA, MessengerConceptsNeonatal rat ventricular cellsAcute myocardial infarctionAnti-arrhythmic efficacyAR expressionMyocardial infarctionBeta 1-adrenergic receptorsRegulation of cardiac functionUp-regulatedAR mRNA levelsRat ventricular cellsProtein levelsAnti-arrhythmic effectsSilencing of let-7eBaseline control levelsForced expressionTonic inhibitionBeta-adrenoceptorVentricular cellsArrhythmia incidenceCardiac functionCritical regulatorsLentivirus vectorRat heartsTherapeutic approachesInfarcted heart
2007
Characterization of Regulatory Elements in the Slc4a1 (Band 3) Locus To Create Safe and Effective Vectors for Globin Gene Therapy
Harrow F, Battle S, Seidel N, Cline A, Gallagher P, Bodine D. Characterization of Regulatory Elements in the Slc4a1 (Band 3) Locus To Create Safe and Effective Vectors for Globin Gene Therapy. Blood 2007, 110: 3740. DOI: 10.1182/blood.v110.11.3740.3740.Peer-Reviewed Original ResearchGene therapyLentiviral vectorsEffective gene therapyGene therapy vectorsHigh-throughput real-time PCRGlobin gene therapyTherapy vectorsGlobin vectorsEcotropic envelopeNew vectorEffective vectorLentivirus vectorHematopoietic stem cellsEnhancer-blocking activityHigh titersSafe deliverySpleen focusTherapeutic levelsErythroid-specific promoterStem cellsΒ-globin promoterLower virus titersNovel strategySafe expressionReporter gene expression
1999
Transduction of Human Progenitor Hematopoietic Stem Cells by Human Immunodeficiency Virus Type 1-Based Vectors Is Cell Cycle Dependent
Sutton R, Reitsma M, Uchida N, Brown P. Transduction of Human Progenitor Hematopoietic Stem Cells by Human Immunodeficiency Virus Type 1-Based Vectors Is Cell Cycle Dependent. Journal Of Virology 1999, 73: 3649-3660. PMID: 10196257, PMCID: PMC104140, DOI: 10.1128/jvi.73.5.3649-3660.1999.Peer-Reviewed Original ResearchConceptsProgenitor hematopoietic stem cellsHematopoietic stem cellsCell cycleG0 cellsStem cellsTransduction ratesG2/M phaseReplication intermediatesCellular factorsHuman immunodeficiency virus type 1 vectorsTransduction efficiencyTransductionAddition of cytokinesM phaseHuman immunodeficiency virus type 1Immunodeficiency virus type 1Presence of cytokinesLentivirus vectorFurther characterizationReverse transcriptionDistinct subpopulationsG2/M fractionVirus type 1CellsTime of initiation
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