Addressing blinding in classic psychedelic studies with innovative active placebos
Aday J, Simonsson O, Schindler E, D’Souza D. Addressing blinding in classic psychedelic studies with innovative active placebos. The International Journal Of Neuropsychopharmacology 2025, 28: pyaf023. PMID: 40183712, PMCID: PMC12038243, DOI: 10.1093/ijnp/pyaf023.Peer-Reviewed Original ResearchConceptsActive placeboClassic psychedelicsPsychedelic studiesAcute psychoactive effectsModerate-to-high dosesPlacebo conditionNeuropsychiatric disordersPsychoactive effectsAcute physiological effectsTherapeutic effectPsychedelicsLow-dose administrationBlind integrationLack of therapeutic effectAcute effectsReview interventionsPlaceboShort-actingClinical trialsPharmacological agentsImproved blindingAncillary strategiesTrialsPhysiological effectsDisorders
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