Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder
Nakamura T, Nakajima K, Kobayashi Y, Itohara S, Kasahara T, Tsuboi T, Kato T. Functional and behavioral effects of de novo mutations in calcium-related genes in patients with bipolar disorder. Human Molecular Genetics 2021, 30: 1851-1862. PMID: 34100076, PMCID: PMC8444452, DOI: 10.1093/hmg/ddab152.Peer-Reviewed Original ResearchConceptsLoss-of-functionBipolar disorderDe novo mutationsCalcium-related genesGenetic architectureAnimal models of bipolar disorderModel of bipolar disorderGenetic architecture of bipolar disorderStudies of bipolar disorderIdentified de novo mutationsLoss-of-function mutationsProtein-altering mutationsMutant miceSchizoaffective disorderBipolar IBehavioral effectsTruncated proteinBehavioral alterationsInhibit endocytosisDiminished attentionKnock-in mouse lineCellular functionsMental illnessBehavioral screeningEHD1
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply