PD-L1 expression as a negative predictive biomarker in advanced esophageal squamous-cell cancer treated with chemotherapy alone
Sachdeva M, Zhao J, Zhu K, Yap D, Wong N, Kumarakulasinghe N, Tey J, Sundar R. PD-L1 expression as a negative predictive biomarker in advanced esophageal squamous-cell cancer treated with chemotherapy alone. ESMO Gastrointestinal Oncology 2025, 7: 100109. DOI: 10.1016/j.esmogo.2024.100109.Peer-Reviewed Original ResearchAdvanced esophageal squamous-cell carcinomaPD-L1 expressionProgression-free survivalFirst-line chemotherapyPD-L1Overall survivalPredictive biomarkersKaplan-MeierKaplan-Meier (KM)Estimate time-to-event outcomesPatients treated with first-line chemotherapyNegative predictor of OSPhase III randomized trialRisk of tumor progressionProgression-free survival analysisPatients treated with chemotherapyCancer treated with chemotherapyNegative predictive biomarkerNon-significant increased riskPD-L1 subgroupsPositive predictive biomarkerEsophageal squamous-cell carcinomaPredictors of OSIndividual Patient Data Meta-AnalysisResponse to immunotherapy
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