Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics
Spitzer A, Johnson K, Nomura M, Garofano L, Nehar-belaid D, Darnell N, Greenwald A, Bussema L, Oh Y, Varn F, D’Angelo F, Gritsch S, Anderson K, Migliozzi S, Gonzalez Castro L, Chowdhury T, Robine N, Reeves C, Park J, Lipsa A, Hertel F, Golebiewska A, Niclou S, Nusrat L, Kellet S, Das S, Moon H, Paek S, Bielle F, Laurenge A, Di Stefano A, Mathon B, Picca A, Sanson M, Tanaka S, Saito N, Ashley D, Keir S, Ligon K, Huse J, Yung W, Lasorella A, Iavarone A, Verhaak R, Tirosh I, Suvà M. Deciphering the longitudinal trajectories of glioblastoma ecosystems by integrative single-cell genomics. Nature Genetics 2025, 57: 1168-1178. PMID: 40346362, PMCID: PMC12081298, DOI: 10.1038/s41588-025-02168-4.Peer-Reviewed Original ResearchConceptsSingle-cell genomicsSingle-nucleus RNA sequencingMalignant cell statesDNA sequencesNeuronal cell typesTumor microenvironmentRNA sequencingMalignant cell fractionCell statesCell typesCell fractionIsocitrate dehydrogenase (IDH)-wildtype glioblastomaStandard-of-care therapyCo-evolutionMolecular heterogeneityTumor microenvironment modifierEcosystemTumor microenvironment compositionSubsets of patientsSequenceRecurrent glioblastoma
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