Neuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues—Liraglutide and Semaglutide
Basalay M, Davidson S, Yellon D. Neuroprotection in Rats Following Ischaemia-Reperfusion Injury by GLP-1 Analogues—Liraglutide and Semaglutide. Cardiovascular Drugs And Therapy 2019, 33: 661-667. PMID: 31721014, PMCID: PMC6994526, DOI: 10.1007/s10557-019-06915-8.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1Middle cerebral artery occlusionReduced infarct sizeImproved neuroscoreInfarct sizeReperfusion therapyAcute ischaemic damageAntagonist exendin(9-39Functional neuroprotective effectsNeuroprotective treatment strategiesGlucagon-like peptide-1 analoguesIschaemia-reperfusion injuryDose-dependent mannerCerebral artery occlusionEffects of liraglutideAcute ischaemic strokeIschaemic stroke patientsNeuroprotective effects of liraglutideExendin(9-39Dose-dependentlyGLP-1RsIschaemia-reperfusionTreatment strategiesSemaglutideArtery occlusion
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