2011
Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction
Wang T. Renal outer medullary potassium channel knockout models reveal thick ascending limb function and dysfunction. Clinical And Experimental Nephrology 2011, 16: 49-54. PMID: 22038261, DOI: 10.1007/s10157-011-0495-0.Peer-Reviewed Original ResearchConceptsThick ascending limbIon transporter expressionRenal outer medullary potassium channelBartter's syndromeInward rectifier potassium channelPotassium channelsSmall-conductance K channelsROMK null miceMedullary thick ascending limbType II Bartter's syndromeSimilar phenotypeMammalian kidneyApical membraneK channelsROMK knockout miceKnockout modelsChannel activityChannel mutationsRenal functionLimb functionNull micePhysiological conditionsSalt wastingTransporter expressionPathophysiological conditions
1995
Permeation Properties and Differential Expression across the Auditory Receptor Epithelium of an Inward Rectifier K+ Channel Cloned from the Chick Inner Ear *
Navaratnam D, Escobar L, Covarrubias M, Oberholtzer J. Permeation Properties and Differential Expression across the Auditory Receptor Epithelium of an Inward Rectifier K+ Channel Cloned from the Chick Inner Ear *. Journal Of Biological Chemistry 1995, 270: 19238-19245. PMID: 7642595, DOI: 10.1074/jbc.270.33.19238.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBariumBase SequenceBasilar MembraneChickensCloning, MolecularDNA, ComplementaryEpitheliumEvoked PotentialsGene Expression RegulationGlutamic AcidHair Cells, AuditoryMolecular Sequence DataPotassium Channel BlockersPotassium ChannelsPotassium Channels, Inwardly RectifyingSequence Homology, Amino AcidXenopusConceptsAuditory receptor epitheliumDifferential expressionSingle-channel conductanceExcellent model systemSite-directed mutagenesisPutative pore regionIon channel genesInward rectifier potassium channelChick inner earCochlear sensory epitheliumReceptor epitheliumChick cochlear hair cellsChannel genesPrimary structureCochlear hair cellsNative channelsRectifier potassium channelSensory epitheliumExternal vestibulePore regionModel systemHair cellsPotassium channelsExpressionInward rectifier potassium current
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