Oncostatin M modulates the biology of cholangiocarcinoma cells and the tumor microenvironment
Porro N, Nurcis J, De Siervi S, Cadamuro M, Turato C, Mantovani S, Oliviero B, Fabris L, Mondelli M, Marra F, Parola M, Caligiuri A, Pastore M, Cannito S, Gentilini A. Oncostatin M modulates the biology of cholangiocarcinoma cells and the tumor microenvironment. Digestive And Liver Disease 2025, 57: s18. DOI: 10.1016/j.dld.2025.01.031.Peer-Reviewed Original ResearchTumor microenvironmentOncostatin MStromal cellsFibrotic tumor microenvironmentPrimary hepatic stellate cellsCultured stromal cellsHuman iCCA cell linesResistance to chemotherapyCell migrationTumor-stroma interactionsDose-dependent increaseExpression of oncostatin MCancer-associated fibroblastsHepatic stellate cellsOncostatin M receptorAggressive tumorsInvasion of iCCA cellsHuman CCA specimensPoor prognosisPeritumoral tissuesCancer-associated pathwaysIncreased cell migrationConditioned mediumTumorCancer cells
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