Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity
Moriyama M, Igarashi M, Koshiba T, Irie T, Takada A, Ichinohe T. Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity. Journal Of Virology 2018, 92: 10.1128/jvi.00706-18. PMID: 30021900, PMCID: PMC6146818, DOI: 10.1128/jvi.00706-18.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceConserved SequenceGene Expression RegulationHost-Pathogen InteractionsHumansInfluenza A Virus, H1N1 SubtypeInterferon Regulatory Factor-3Interferon-betaInterleukin-1betaNLR Family, Pyrin Domain-Containing 3 ProteinPhlebotomus FeverPhlebovirusPhosphorylationPromoter Regions, GeneticProtein Serine-Threonine KinasesProtein TransportSequence AlignmentSeverity of Illness IndexSignal TransductionUbiquitinationViral Nonstructural ProteinsViruses, UnclassifiedConceptsTANK-binding kinase 1SFTSV nonstructural proteinInterferon regulatory factor 3Nonstructural proteinsHost antiviral responseCytoplasmic structuresAmino acidsInterferon-beta productionKinase 1N-terminal kinase domainTick-borne phlebovirusesSFTS phlebovirusConserved amino acidsAntiviral responseC-terminal regionN-terminal regionIFN-β promoter activityPosition 21Host antiviral strategyHost innate immune systemThrombocytopenia syndrome phlebovirusRegulatory factor 3Host interferon responseKinase domainIFN-β production
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