α-Branched amines by catalytic 1,1-addition of C–H bonds and aminating agents to terminal alkenes
Maity S, Potter TJ, Ellman JA. α-Branched amines by catalytic 1,1-addition of C–H bonds and aminating agents to terminal alkenes. Nature Catalysis 2019, 2: 756-762. PMID: 32879907, PMCID: PMC7462361, DOI: 10.1038/s41929-019-0330-7.Peer-Reviewed Original ResearchTerminal alkenesH bond substratesOne-step synthesisHigh functional group compatibilityFunctional group compatibilityChiral catalystsBranched aminesFeedstock chemicalsConvergent synthesisH bondsAsymmetric synthesisN bondAddition pathwayRhodium precatalystGroup compatibilityMild conditionsBond substratesIntermolecular formationDrug structureAminesSynthesisAlkenesClinical candidatesBondsΑ-methyl
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