Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells
Kim M, Kim H, Jeong J, Shim Y, Lee J, Kim Y, Ryu T, Yang K, Kim K, Jeon B, Kim S, Jung J, Choi J, Lee Y, Byun J, Jeong W. Ginsenoside F2 attenuates chronic-binge ethanol-induced liver injury by increasing regulatory T cells and decreasing Th17 cells. Journal Of Ginseng Research 2020, 44: 815-822. PMID: 33192125, PMCID: PMC7655498, DOI: 10.1016/j.jgr.2020.03.002.Peer-Reviewed Original ResearchAttenuates alcoholic liver injuryDifferentiation of naive T cellsAlcoholic liver injuryRegulatory T cellsNaive T cellsT cellsTh17 cellsLiver injuryFrequency of Foxp3<sup>+</sup> regulatory T cellsIL-10Foxp3<sup>+</sup> regulatory T cellsIL-17-producing TInduce alcoholic liver injuryIncreased regulatory T cellsIL-10 KO miceInfiltration of inflammatory macrophagesDecreased IL-17 expressionMRNA expressionIL-17 mRNA expressionAlcoholic liver inflammationInterleukin (IL)-10 knockoutMice compared to controlsDecreased Th17 cellsIncreased IL-10 expressionEthanol-induced liver injury
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