Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis
Marchal-Duval E, Homps-Legrand M, Froidure A, Jaillet M, Ghanem M, Lou D, Justet A, Maurac A, Vadel A, Fortas E, Cazes A, Joannes A, Giersh L, Mal H, Mordant P, Piolot T, Truchin M, Mounier C, Schirduan K, Korfei M, Gunther A, Mari B, Jaschinski F, Crestani B, Mailleux A. Identification of Paired-related Homeobox Protein 1 as a key mesenchymal transcription factor in pulmonary fibrosis. ELife 2023, 12: e79840. PMID: 37261432, PMCID: PMC10275639, DOI: 10.7554/elife.79840.Peer-Reviewed Original ResearchConceptsIdiopathic pulmonary fibrosisMesenchymal transcription factorsPulmonary fibrosisMouse precision-cut lung slicesMouse model of lung fibrosisTGF-bModel of lung fibrosisLung fibroblastsPrecision-cut lung slicesBleomycin mouse modelIdiopathic pulmonary fibrosis treatmentHuman lung fibroblast proliferationIPF human lung fibroblastsMatrix remodelingTranscription factorsInhibiting Smad2/3 phosphorylationLung fibroblast proliferationHuman lung fibroblastsS phase cyclinsLung fibrosisHomeobox protein 1Remodeling in vivoLung fibrogenesisSmad2/3 phosphorylationTargeted inhibition
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