Sodium chloride versus glucose solute as a volume replacement therapy for more effective decongestion in acute heart failure (SOLVRED‐AHF): A prospective, randomized, mechanistic study
Biegus J, Iwanek G, Testani J, Zymliński R, Fudim M, Guzik M, Gajewski P, Ponikowski P. Sodium chloride versus glucose solute as a volume replacement therapy for more effective decongestion in acute heart failure (SOLVRED‐AHF): A prospective, randomized, mechanistic study. European Journal Of Heart Failure 2025 PMID: 40455066, DOI: 10.1002/ejhf.3708.Peer-Reviewed Original ResearchAcute heart failureProximal tubular sodium reabsorptionCo-primary endpointsTubular sodium reabsorptionNaCl groupEffective decongestionDiuretic therapyUrine outputSodium reabsorptionHeart failureCumulative dose of furosemideGlucose groupFractional excretion of lithiumDose of furosemideMedian urine outputAbsolute distal reabsorptionVolume replacement therapyExcretion of lithiumSingle-blind studyInfusion of NaClInhibition of proximal tubular sodium reabsorptionFurosemide doseFluid overloadCumulative doseDecongestive effect
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply