2003
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
Petersen KF, Befroy D, Dufour S, Dziura J, Ariyan C, Rothman DL, DiPietro L, Cline GW, Shulman GI. Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance. Science 2003, 300: 1140-1142. PMID: 12750520, PMCID: PMC3004429, DOI: 10.1126/science.1082889.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdolescentAdultAgedAged, 80 and overAgingBlood GlucoseBody Mass IndexFemaleHumansInsulinInsulin ResistanceLiverMaleMiddle AgedMitochondriaMitochondrial DiseasesMuscle, SkeletalNuclear Magnetic Resonance, BiomolecularOxidation-ReductionOxygen ConsumptionPhosphorylationTriglyceridesConceptsInsulin resistanceInsulin-stimulated muscle glucose metabolismType 2 diabetesMuscle glucose metabolismLean body massElderly study participantsAge-associated declineMitochondrial function contributesFat massFat accumulationGlucose metabolismYoung controlsStudy participantsLiver tissueFunction contributesMitochondrial dysfunctionYounger participantsPossible roleMitochondrial oxidativeBody massMagnetic resonance spectroscopyParticipantsDiabetesDysfunctionPathogenesis
1999
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade.
Griffin ME, Marcucci MJ, Cline GW, Bell K, Barucci N, Lee D, Goodyear LJ, Kraegen EW, White MF, Shulman GI. Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade. Diabetes 1999, 48: 1270-1274. PMID: 10342815, DOI: 10.2337/diabetes.48.6.1270.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDeoxyglucoseEnzyme ActivationFatty Acids, NonesterifiedInsulinInsulin Receptor Substrate ProteinsInsulin ResistanceIsoenzymesMagnetic Resonance SpectroscopyMaleMuscle, SkeletalPhosphatidylinositol 3-KinasesPhosphoproteinsPhosphorylationProtein Kinase CProtein Kinase C-thetaRatsRats, Sprague-DawleySignal TransductionTyrosineZinc FingersConceptsProtein kinase C thetaGlucose transport activityInsulin resistanceMuscle glycogen synthesisFree fatty acidsC thetaInsulin-stimulated insulin receptor substrateInsulin-stimulated IRS-1 tyrosine phosphorylationTransport activityIRS-1 tyrosine phosphorylationReduced glucose transport activityInsulin-stimulated muscle glucose metabolismFatty acid-induced insulin resistance
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